姓名：王军

职称：教授

职务：口腔正畸科主任

所在学系：口腔正畸学系

研究生导师类别：博导

电子邮箱：wangjunv@163.com

办公地址：四川省成都市人民南路三段14号华西口腔医院正畸科

研究方向：

　　1.正畸牙移动生物学及生物力学

　　2.组织再生与修复

　　3.数字化与人工智能在口腔正畸的应用

个人简介

四川大学华西口腔医学院教授、博士研究生导师，中华口腔医学会正畸专业委员会 常委，中华口腔医学会计算机专业委员会委员，四川省口腔医学会正畸专业委员会副主任委员，教育部新世纪人才项目获得者，四川省卫生健康委学术技术带头人，四川省学术和技术带头人后备人选，先后主持国家自然科学基金7项，相关工作以第一作者或通讯作者发表在AFM、JDR、AJO等权威期刊。获授权专利10项，基于人工智能主导研发正畸头影测量系统（Uceph）和正畸图片智能管理系统（Usorter）各1项，已成功转化并广泛应用于口腔临床教学科研。

研究领域

主要科研项目：

1. 正畸应力刺激对骨髓间充质干细胞多向分化生物学行为的影响，国家自然科学基金10402027， 2005-2007，负责人

2. 间充质干细胞移植对正畸力作用下牙周组织改建的影响 国家自然科学基金30870597 ，2009-2011 负责人

3. 正畸应力刺激下MSCs对慢性牙周炎局部T细胞功能调节作用的研究 国家自然科学基金31070825， 2011-2013负责人

4. EndMT在正畸牙周改建中的作用及机制研究，国家自然科学基金81271718/H1822, 2013-2016，负责人

5. TNF-α/NF-κB信号通路在正畸牙移动中PDLSCs介导的炎症调控中的作用及机制研究国家自然科学基金81470776， 2015-2018，负责人

6. Gli1+细胞在TMJ骨关节炎修复中的稳态调节作用及机制研究  国家自然科学基金81771114， 2018-2021，负责人

7. 靶向调控周细胞PDGFR-β信号通路对拔牙正畸牙槽骨-血管重塑的影响及机制研究  国家自然科学基金81970967，2020-2023，负责人

8. MSCs免疫调节功能对正畸牙移动过程的干预研究 ，教育部新世纪优秀人才支持计划，2010-2012，负责人

9. EndMT在正畸牙周改建的作用机制及低氧对其的影响研究，教育部博士点基金20120181110003，负责人

论文/著作：

　　代表论文：

　　1.Zhanrong Jia  Jinglei Gong  Yan Zeng  Jinhui Ran  Jing Liu  Kefeng Wang  Chaoming Xie*  Xiong Lu* Jun Wang*.  Bioinspired Conductive Silk Microfiber Integrated Bioelectronic for Diagnosis and Wound Healing in Diabetes, Advanced Functional Materials, 2021,

　　2.X.Y. Fang, Y.X. Zhan, L.N. Wu, J. Lin, Z.H. Zhang, C.X.Y. Ye, C.M. Jiang, Y.T. Yi, J. Wang*, J. Liu*. CXCL12/CXCR4 Mediates Orthodontic Root Resorption via Regulating the M1/M2 Ratio. Journal of Dental Research. 2021, DOI: 10.1177/00220345211050324

　　3.An S, Zhang Y, Chen Q, Xiong B, Hao J, Zheng Y, Zhou X,?Wang J*. Effect of systemic delivery of Substance P on experimental tooth movement in rats.Am J Orthod Dentofacial Orthop. 2019 May;155(5):642-649.

　　4.Jiang C, Liu Y, Cheng Q, He W, Fang S, Lan T, Wang J*. Chin remodeling in a patient with bimaxillary protrusion and open bite by using mini-implants for temporary anchorage.Am J Orthod Dentofacial Orthop. 2018;153(3):436-444

　　5.C.M. Jiang, J. Liu, J Wang*. Effects of Hypoxia on the Immunomodulatory Properties of Human Gingiva–Derived Mesenchymal Stem Cells. Journal of Dental Research 2015, 94(1) 69 –77

其他论文：

　　1. Xueman Zhou, Yingcheng Zheng,Wentian Sun,Zhenzhen Zhang,Jiaqi Liu,Wenke Yang,Wenxiu Yuan,Yating Yi, Jun Wang*, Jin Liu*, D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner. Cell Prolif. 2021,https://doi.org/10.1111/cpr.13134

　　2. Zhenzhen Zhang, Xueman Zhou, Jiaqi Liu, Yingcheng Zheng, Yange Wu, Wenke Yang, Yating Yi, Jin Liu*, Jun Wang*. D-mannose Attenuates Lipopolysaccharide-induced Osteolysis via CPT1A-Mediated Lipid Metabolic Regulation in Macrophages. Biochemical and Biophysical Research Communications. 2021 Oct 8;583:135-141. doi: 10.1016/j.bbrc.2021.10.020.

　　3. Dehua Wu, Xinyi Fang, Jintong Song, Lang Qu, Xiangge Zhou, Haifeng Xiang*, Jun Wang *, Jin Liu*, (2021). Multi-stimuli-responsive fluorescence of axially chiral 4-ene-β-Diketones. Dyes and Pigments 184, 108851:1-11

　　4. Yi Y, Zhou X, Xiong X, Wang J*. Neuroimmune interactions in painful TMD: Mechanisms and treatment implications. J Leukoc Biol. 2021 Sep;110(3):553-563. doi: 10.1002/JLB.3MR0621-731RR

　　5. Yi Y, Xie C, Liu J, Zheng Y, Wang J*, Lu X*. Self-adhesive hydrogels for tissue engineering. J Mater Chem B. 2021 Oct 14. doi: 10.1039/d1tb01503f.

　　6. Huang Y, Sun W, Xiong X, Zhang Z, Liu J, Wang J*. Effects of fixed functional appliances with temporary anchorage devices on Class II malocclusion: A systematic review and metaanalysis. J World Fed Orthod. 2021 Jun;10(2):59-69. doi: 10.1016/j.ejwf.2021.02.001

　　7. Wu Y, Xiong X, Fang X, Sun W, Yi Y, Liu J, Wang J*. Psychological status of TMD patients, orthodontic patients and the general population during the COVID-19 pandemic. Psychol Health Med. 2021 Jan;26(1):62-74. doi: 10.1080/13548506.2020.1858489. Epub 2020 Dec 21.

　　8. Xueman Zhou, Wenxiu Yuan, Xin Xiong, Zhenzhen Zhang, Jiaqi Liu, Yingcheng Zheng, Jun Wang*, Jin Liu*. HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis, Frontiers Cell and Developmental Biology DOI: 10.3389/fcell.2021.791585

　　9. Xiong X, Wu Y, Fang X, Sun W, Ding Q, Yi Y, Huang Y, Gong J, Liu J, Wang J*. Mental distress in orthodontic patients during the coronavirus disease 2019 pandemic. Am J Orthod Dentofacial Orthop. 2020 Jul 10:S0889-5406(20)30412-1. doi: 10.1016/j.ajodo.2020.07.005.

　　10. Xiong X, Huang Y, Liu W, Wu Y, Yi Y, Wang J*. Distribution of Various Maxilla-Mandibular Positions and Cephalometric Comparison in Chinese Skeletal Class II Malocclusions. J Contemp Dent Pract 2020;21(8):822–828. doi: 10.5005/jp-journals-10024-2897.

　　11. Caiqi Cheng , Tian Xie , Jun Wang*. The efficacy of analgesics in controlling orthodontic pain: a systematic review and meta-analysis. BMC Oral Health (2020) 20:259-267

　　12. Xuemei Xu, Xueman Zhou, Lang Qu, Lei Wang, Jintong Song, Dehua Wu, Weilan Zhou, Xiangge Zhou, Haifeng Xiang*, Jun Wang*, and Jin Liu*.Reversible Chromatic Change of Supramolecular Gels for Visual and Selective Chiral Recognition of Histidine ACS Appl. Bio Mater. 2020, 3, 7236−7242

　　13. Yating Yi , Yi Men , Dian Jing , Wenjing Luo , Shiwen Zhang , Jian Q Feng , Jin Liu , Woo-Ping Ge , Jun Wang* , Hu Zhao*. 3-dimensional visualization of implant-tissue interface with the polyethylene glycol associated solvent system tissue clearing method. Cell Prolif. 2019 ;52(3):e12578. doi: 10.1111/cpr.12578

　　14. Zhang Y, An S, Hao J, Tian F, Fang X, Wang J*. Systemic Injection of Substance P Promotes Murine Calvarial Repair Through Mobilizing Endogenous Mesenchymal Stem Cells. Sci Rep. 2018; 8(1):12996

　　15. Gou Y, Li J, Merrill A, Wang J*，Xu J. Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018; 152:13-20.

　　16. Jiang C, Yi Y, Jiang C, Fang S, Wang J*. Pharyngeal Airway Space and Hyoid Bone Positioning After Different Orthognathic Surgeries in Skeletal Class II Patients. J Oral Maxillofac Surg. 2017;75(7):1482-1490.

　　17. Chen Y, Wang M, Chen D, Wang J*, Kang N..Chromatin remodeling enzyme CHD7 is necessary for osteogenesis of human mesenchymal stem cells.Biochem Biophys Res Commun. 2016 Sep 30;478(4):1588-93.(共同通讯)

　　18. Yu W, Zhang Y, Jiang C, He W, Yi Y, Wang J*. Orthodontic treatment mediates dental pulp microenvironment via IL17A. Arch Oral Biol. 2016 Jun; 66:22-9.

　　19. C Jiang， Z Li， S An, J Wang*, Osteoimmunology in orthodontic tooth movement，Oral Diseases 2015, 21(6):694-704

　　20. Yu WJ,Liu Z, An S, Zhao JY, Xiao L, Gou YC, Lin YF, Wang J*. The endothelial-mesenchymal transition and tissue regeneration Current Stem Cell Research & Therapy 2014(9)3：196-204

　　21. Wang Y, Yu H, Jiang C, Wang J*. Vertical changes in Class I malocclusion between 2 different extraction patterns. Saudi Med J. 2013; 34(3):302-6.

　　22. Li Z, Jiang CM, An S, Cheng Q, Huang YF, Wang YT, Gou YC, Xiao L, Yu WJ, Wang J*. Immunomodulatory properties of dental tissue-derived mesenchymal stem cells. Oral Dis. 2014; 20(1):25-34

　　23. Yi-fan Huang, Qian Cheng, Chun-miao Jiang, Shu An, Lan Xiao, Yong-chao Gou, Wen-jing Yu, Lei Lei, Qian-ming Chen, YatingWang, and Jun Wang*. The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren’s Syndrome, Clinical and Developmental Immunology, Clin Dev Immunol. 2013;2013:160491. doi: 10.1155/2013/160491