姓名：石思容 

职称：副研究员

职务：四川省口腔生物材料工程研究中心副主任 

所在学系：口腔基础医学系

研究生导师类别：硕导 

联系方式：sirongshi@scu.edu.cn 

研究领域：核酸纳米材料及其改性结构对软骨及骨再生应用研究

个人简介

四川大学华西口腔医学院口腔疾病防治全国重点实验室副研究员，四川省口腔生物材料工程研究中心副主任，德克萨斯农工大学访问学者。四川省口腔医学会口腔材料专业委员会常务委员兼秘书；四川省口腔医学会口腔生物学专业委员会委员；中国医学装备协会组织再生分会委员；中国生物材料学会会员；四川省科技青年联合会会员；杂志Frontiers in Bioengineering and Biotechnology的评论编辑。主要从事DNA核酸纳米材料研究，解决了核酸纳米材料的结构改性升级以及骨关节炎治疗相关问题。迄今已发表SCI论文61篇，其中以第一作者或通讯作者发表B级学术论文26篇，包括Nature Protocols, Advanced Materials, Advanced Functional Materials, ACS Nano, Bone Research, Chemical Engineering Journal , Bioactive Materials, J Control Release, ACS Applied Materials & Interfaces, Chemical Communication, Nanoscale等刊物。授权国家发明专利2项、授权美国专利1项，参与编写英文专著二部。主持国自然青年基金，省科技厅青年基金，博士后站中和博士后面上等项目（国家/省部级）、到校经费共计66万元。荣获自然科学奖二等奖（高等学校科学研究优秀成果奖），2022年中华医学科技奖青年科技奖等。 

论文/著作

1. Shi, S#.; Chen, T#.; Lu, W.; Chen, Y.; Xiao, D.; Lin, Y., Amelioration of Osteoarthritis via Tetrahedral Framework Nucleic Acids Delivering Microrna-124 for Cartilage Regeneration. Adv Funct Mater 2023, 33(46), 2305558

2. Tian, T#.; Zhang, T#.; Shi, S#.; Gao, Y.; Cai, X.; Lin, Y., A dynamic DNA tetrahedron framework for active targeting. Nat Protoc 2023, 18(4):1028-1055.

3. Li, J#.; Yao, Y#.; Wang, Y.; Xu, J.; Zhao, D.; Liu, M.; Shi, S*.; Lin, Y*., Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System. Adv Mater 2022, 34(46):e2202513.

4. Yuting Xie#, Sirong Shi#, Weitong Lv, Xinyu Wang, Lin Yue, Conghui Deng, Doudou Wang, Jing Han, Tinghong Ye*, Yunfeng Lin*. Tetrahedral Framework Nucleic Acids Delivery of Pirfenidone for Anti-Inflammatory and Antioxidative Effects to Treat Idiopathic Pulmonary Fibrosis. ACS Nano. 2024 Sep 14. doi: 10.1021/acsnano.4c06598. 

5. Ruijianghan Shi, Yujie Zhu, Yang Chen, Yunfeng Lin*, Sirong Shi*. Advances in DNA nanotechnology for chronic wound management: Innovative functional nucleic acid nanostructures for overcoming key challenges. J Control Release. 2024 Sep 8:375:155-177. 

6. Liwei Fu#, Jiang Wu#, Sirong Shi#, Zhichao Zhang, Yazhe Zheng, Pinxue Li, Xun Yuan, Zhengang Ding, Chao Ning, Xiang Sui, Shuyun Liu, Quanyi Guo, Yunfeng Lin. A tetrahedral framework nucleic acids-based gene therapeutic nanococktail alleviates cartilage damage and protects against osteoarthritis progression. Chemical Engineering Journal 2024 498(15), 155189.

7. Liwei Fu, Jiang Wu, Pinxue Li, Yazhe Zheng, Zhichao Zhang, Xun Yuan, Zhengang Ding, Chao Ning, Xiang Sui, Shuyun Liu*, Sirong Shi*, Quanyi Guo*, Yunfeng Lin*. A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage. Bioactive Materials 2024 40, 634-648.

8. Cai, Z.; Liu, F.; Li, Y.; Bai, L.; Feng, M.; Li, S.; Ma, W.; Shi, S*., Functional micro-RNA drugs acting as a fate cog in the regulation of osteoblastic demise. Nanoscale 2023 15(31):12840-12852.

9. Shi, S.; Li, Y.; Zhang, T.; Xiao, D.; Tian, T.; Chen, T.; Zhang, Y.; Li, X.; Lin, Y., Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution. ACS Appl Mater Interfaces 2021, 13 (48), 57067-57074.

10. Lin, Y*.; Li, Q.; Wang, L.; Guo, Q.; Liu, S.; Zhu, S.; Sun, Y.; Fan, Y.; Sun, Y.; Li, H.; Tian, X.; Luo, D.; Shi, S*., Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation. Int J Oral Sci 2022, 14(1): 51.

11. Shi, S#.; Chen, Y#.; Tian, T.; Li, S.; Lin, S.; Shao, S.; Zhang, T.; Lin, Y.; Cai, X., Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis. Bone research 2020, 8, 6.